4-Bromo-1H-pyrrole-2-carboxylic acid(CAS: 27746-02-7)

4-Bromo-1H-pyrrole-2-carboxylic acid is a crystalline solid with a molecular weight of approximately 207.02 g/mol. It is slightly soluble in water and has a pKa of around 2.0. This compound is reactive, particularly towards nucleophiles, and can undergo bromination and esterification reactions.

4-Bromo-1H-pyrrole-2-carboxylic acid can be synthesized through bromination of 1H-pyrrole-2-carboxylic acid using N-bromosuccinimide (NBS) in an appropriate solvent like dichloromethane under light or heat. The reaction typically yields a mixture that can be purified by recrystallization or chromatography.

4-Bromo-1H-pyrrole-2-carboxylic acid is primarily used in the pharmaceutical industry for the synthesis of novel drug candidates, as well as in the polymer industry for the development of advanced materials. It also finds applications in sensor technology and semiconductor manufacturing due to its unique chemical properties.

When handling 4-Bromo-1H-pyrrole-2-carboxylic acid, it is crucial to use appropriate personal protective equipment (PPE), including gloves and safety goggles. This compound should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of spill, it should be handled using appropriate spill kits and safety protocols. Always refer to the Material Safety Data Sheet (MSDS) for detailed information and emergency procedures.