2,5-Difluorophenol(CAS: 2713-31-7)

2,5-Difluorophenol (CAS: 2713-31-7) is a colorless crystalline solid with a molecular weight of approximately 141.04 g/mol. It has a pKa of about 10.3 and is slightly soluble in water. It is reactive towards bases and can undergo substitution reactions. The substance has a density of about 1.25 g/cm³ and a melting point of 45-46°C.

2,5-Difluorophenol is typically synthesized by the reduction of 2,5-difluorophenone or through the hydrogenation of 2,5-difluorophenyl ketone. Common methods include the use of hydrogen gas in the presence of a catalyst like palladium on carbon. The reaction is exothermic and selective, yielding a high purity product with good yield.

2,5-Difluorophenol is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of drugs. It is also utilized in the production of polymers, specifically in the development of thermosetting resins. Additionally, it plays a role in the manufacturing of sensors and semiconductors due to its chemical properties.

When handling 2,5-Difluorophenol (CAS: 2713-31-7), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Handle in a well-ventilated area or fume hood due to its potential to release toxic gases during reactions. Follow strict procedures for spill cleanup and ensure proper storage in a cool, dry place away from incompatible materials. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.