4-(Bromomethyl)-2-chlorobenzonitrile(CAS: 83311-25-5)

4-(Bromomethyl)-2-chlorobenzonitrile is a white crystalline solid with a molecular weight of approximately 271.01 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. The compound is reactive and undergoes substitution reactions readily, especially with nucleophiles.

4-(Bromomethyl)-2-chlorobenzonitrile is typically synthesized via a substitution reaction of 2-chlorobenzonitrile with bromomethyl ketone in the presence of a base such as potassium carbonate. The reaction is carried out in an organic solvent like acetonitrile, yielding a high selectivity and good yield.

4-(Bromomethyl)-2-chlorobenzonitrile is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of medicinals. It also finds applications in the production of polymers, sensors, and as a precursor in semiconductor manufacturing processes.

When handling 4-(Bromomethyl)-2-chlorobenzonitrile, it is crucial to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated fume hood to minimize inhalation exposure. Spills should be cleaned up carefully using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.