Benzyl 3-hydroxybenzoate(CAS: 77513-40-7)

Benzyl 3-hydroxybenzoate is a white crystalline solid with a molecular weight of approximately 238.25 g/mol. It has a melting point of 68-70°C and is slightly soluble in water but more soluble in organic solvents such as ethanol and acetone. It is generally stable under normal conditions but may react with strong acids or bases. It is not flammable but should be stored in a cool, dry place away from direct sunlight.

Benzyl 3-hydroxybenzoate can be synthesized via a Friedel-Crafts acylation of hydroxybenzoic acid with benzyl chloride in the presence of a Lewis acid catalyst like aluminum chloride. The reaction is typically carried out in a polar aprotic solvent such as dichloromethane. The yield is usually around 70-80%, and the selectivity is good, with minimal formation of byproducts.

Benzyl 3-hydroxybenzoate is used in the pharmaceutical industry as a raw material for the synthesis of various drugs. It is also used in the polymer industry as a stabilizer and plasticizer. In addition, it finds applications in the fragrance industry as a flavor and fragrance component, in cosmetics, and in the food industry as a flavoring agent. It is also used in the production of sensors and semiconductors.

When handling Benzyl 3-hydroxybenzoate, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety glasses. It should be handled in a well-ventilated area or under a fume hood to minimize inhalation risk. If a spill occurs, it should be cleaned up carefully, and the area should be flushed with water. In case of eye or skin contact, immediate washing with copious amounts of water is recommended. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.