2-(4,4-Difluorocyclohexyl)acetic acid(CAS: 915030-40-9)

2-(4,4-Difluorocyclohexyl)acetic acid is a colorless solid with a crystalline form. Its molecular weight is approximately 242.14 g/mol. Its solubility in water is low, approximately 0.2 g/L at 25°C. It is less reactive compared to other carboxylic acids but can undergo esterification and acid-base reactions. It is not flammable but may require cooling during synthesis to maintain its crystalline form.

2-(4,4-Difluorocyclohexyl)acetic acid is typically synthesized via the reaction of 4,4-difluorocyclohexanol with acetic anhydride in the presence of a suitable catalyst. Commonly, this is done under mild conditions to achieve high selectivity and yield. The process requires careful control of temperature and reaction time to optimize product purity and minimize side reactions.

2-(4,4-Difluorocyclohexyl)acetic acid has applications in pharmaceuticals, where it serves as a precursor in the synthesis of active pharmaceutical ingredients. It is also used in polymer chemistry for modifying polymer properties, in sensors for detection applications, and in the production of semiconductors for electronic devices. Its unique chemical structure makes it valuable in these specialized industries.

When handling 2-(4,4-Difluorocyclohexyl)acetic acid, it is important to use appropriate Personal Protective Equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to prevent inhalation of vapors. Spills should be cleaned up immediately using absorbent material, followed by thorough cleaning with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.