1-(6-Chloro-3-pyridinyl)ethanone(CAS: 55676-22-7)

1-(6-Chloro-3-pyridinyl)ethanone (CAS: 55676-22-7) is a crystalline solid with a molecular weight of approximately 187.01 g/mol. It has a solubility of about 5 g/L in water at 25°C. This compound is moderately reactive, particularly towards nucleophiles and bases. It can undergo electrophilic aromatic substitution reactions under certain conditions.

1-(6-Chloro-3-pyridinyl)ethanone (CAS: 55676-22-7) can be synthesized via the condensation of chloroacetyl chloride with 3-chloropyridine. This reaction typically proceeds in an organic solvent like dichloromethane with a catalytic amount of an acid like sulfuric acid. The yield is generally around 70-80%, and the reaction is selective for the desired product.

1-(6-Chloro-3-pyridinyl)ethanone (CAS: 55676-22-7) finds application in various industries, particularly in pharmaceuticals where it serves as an intermediate for the synthesis of drugs. It is also utilized in the production of certain organic compounds and as a reagent in chemical research and development.

When handling 1-(6-Chloro-3-pyridinyl)ethanone (CAS: 55676-22-7), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Fume hood use is recommended during operations to minimize inhalation risks. Ensure proper ventilation and store the compound in a cool, dry place away from oxidizing agents. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.