3-Chloro-2-methoxypyridine(CAS: 13472-84-9)

3-Chloro-2-methoxypyridine is a crystalline solid with a molecular weight of approximately 166.58 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetonitrile. The compound is moderately reactive towards nucleophiles and electrophiles, making it useful in various organic syntheses. It is slightly acidic and can undergo substitution reactions with bases and nucleophiles.

3-Chloro-2-methoxypyridine is commonly synthesized through the reaction of 2-methoxypyridine with chlorine gas in the presence of a Lewis acid catalyst, such as aluminum trichloride. The synthesis yields a pure product with high selectivity and good yield, making it a reliable method for industrial production.

3-Chloro-2-methoxypyridine is utilized in the pharmaceutical industry for the synthesis of certain medicinal compounds. It also finds applications in the polymer industry as a monomer or intermediate, and in the sensor industry due to its unique chemical properties that make it sensitive to specific analytes. Additionally, it can be used in the semiconductor industry for specific processing steps.

When handling 3-Chloro-2-methoxypyridine, it is essential to use appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure to the compound. Spills should be cleaned up immediately using appropriate absorbents, and proper disposal methods should be followed. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.