4-Bromo-1,2-benzoxazole(CAS: 1126848-34-7)

4-Bromo-1,2-benzoxazole is a crystalline solid with a molecular weight of 226.01 g/mol. It has a melting point of 98-100°C. This compound is slightly soluble in water and more soluble in solvents like ethanol and acetone. It is reactive towards nucleophiles and exhibits good stability under acidic and basic conditions.

4-Bromo-1,2-benzoxazole can be synthesized via bromination of 1,2-benzoxazole using N-bromosuccinimide (NBS) in the presence of a radical initiator like benzoyl peroxide. This method provides high yield and good selectivity for the brominated product.

4-Bromo-1,2-benzoxazole finds applications in the pharmaceutical industry for the synthesis of certain drugs, as well as in the polymer industry for the modification of polymers. It is also used in the development of sensors and semiconductor materials due to its unique electronic properties.

Proper personal protective equipment (PPE) such as gloves, goggles, and lab coat should be worn when handling 4-Bromo-1,2-benzoxazole. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation. Spills should be cleaned up using absorbent material, and proper disposal methods should be followed as per local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.