2-Chloro-5-fluorophenol(CAS: 3827-49-4)

2-Chloro-5-fluorophenol (CAS: 3827-49-4) is a white or off-white crystalline solid with a molecular weight of 156.01 g/mol. It has a melting point of 61-62°C and a solubility of 21.5 g/L in water. It is moderately reactive, particularly with bases and reducing agents. It is used in organic synthesis and as an intermediate in the production of dyes and pharmaceuticals.

2-Chloro-5-fluorophenol (CAS: 3827-49-4) is typically synthesized by the chlorination of 5-fluoro-m-phenylenediamine. This process involves the use of thionyl chloride as a chlorinating agent. The reaction is carried out under anhydrous conditions, and the yield is around 90%. The reaction is selective and produces the desired product with high purity.

2-Chloro-5-fluorophenol (CAS: 3827-49-4) is used in the pharmaceutical industry as an intermediate for the synthesis of certain drugs. It also finds applications in the production of dyes, pesticides, and as an additive in various chemical formulations. Additionally, it is used in the preparation of functional materials and in some analytical and sensor applications.

When handling 2-Chloro-5-fluorophenol (CAS: 3827-49-4), it is essential to wear proper personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation or skin contact. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage recommendations.