4-Ethyl-2-piperazinone hydrochloride (1:1)(CAS: 65464-00-8)

4-Ethyl-2-piperazinone hydrochloride (CAS: 65464-00-8) is a white crystalline solid with a molecular weight of approximately 240.7 g/mol. It has a pKa of 2.0, indicating it is a weak acid. The compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It exhibits good stability under normal conditions but is reactive towards bases. It is often used as a starting material in organic synthesis due to its reactivity and functional groups.

4-Ethyl-2-piperazinone hydrochloride (CAS: 65464-00-8) is typically synthesized by reacting 2-piperazinone with ethyl bromide in the presence of a base like sodium hydroxide. The reaction is conducted in an aprotic solvent such as dimethylformamide. The yield is generally high, around 80-90%, and the product is isolated by recrystallization from ethanol. Other methods include direct ethylation of 2-piperazinone using ethyl iodide under similar conditions.

4-Ethyl-2-piperazinone hydrochloride (CAS: 65464-00-8) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the polymer industry for the production of polyurethanes and other polymers. Additionally, it finds applications in the development of sensors and semiconductors due to its unique chemical properties and reactivity.

When handling 4-Ethyl-2-piperazinone hydrochloride (CAS: 65464-00-8), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be handled carefully, and the area should be flushed with water. It is important to consult the Safety Data Sheet (SDS) for detailed emergency response information and storage recommendations. The compound should be stored in a cool, dry place away from incompatible materials.