5-Bromo-1H-indazole(CAS: 53857-57-1)

5-Bromo-1H-indazole (CAS: 53857-57-1) is a crystalline solid with a molecular weight of approximately 183.03 g/mol. It is slightly soluble in water but readily soluble in organic solvents like acetone and dichloromethane. The compound shows weak basicity and moderate reactivity towards nucleophiles. It is stable under normal laboratory conditions, but care must be taken to avoid prolonged exposure to air and light.

5-Bromo-1H-indazole (CAS: 53857-57-1) is typically synthesized via the bromination of 1H-indazole in the presence of a phase transfer catalyst like tetrabutylammonium bromide. The reaction proceeds under mild conditions, resulting in a high yield of the desired product with good regioselectivity. The process is efficient and can be scaled up for industrial production.

5-Bromo-1H-indazole (CAS: 53857-57-1) is primarily used in the pharmaceutical industry for the synthesis of various heterocyclic compounds and bioactive molecules. It also finds applications in the development of sensors and semiconductors due to its unique electronic properties. Additionally, it is utilized in the polymer industry for the preparation of functional polymers.

When handling 5-Bromo-1H-indazole (CAS: 53857-57-1), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of a spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and safety information.