4-(4-Isopropyl-1-piperazinyl)phenol(CAS: 67914-97-0)

4-(4-Isopropyl-1-piperazinyl)phenol (CAS: 67914-97-0) is a white crystalline solid. Its molecular weight is approximately 277.46 g/mol. The compound is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. It is moderately reactive, showing limited reactivity with common acids and bases. It has a melting point of 184-186°C. It is stable under normal storage conditions but should be protected from strong oxidizing agents.

4-(4-Isopropyl-1-piperazinyl)phenol (CAS: 67914-97-0) can be synthesized via a multi-step process starting from p-toluidine and 4-hydroxypiperidine. The synthesis involves a condensation reaction followed by an isopropylation step. Commonly, potassium carbonate is used as a base, and the reaction is typically carried out in an organic solvent like tetrahydrofuran (THF). The yield is around 75-80%, and the reaction is known for its good selectivity and moderate to high purity.

4-(4-Isopropyl-1-piperazinyl)phenol (CAS: 67914-97-0) is primarily used in the pharmaceutical industry, particularly in the development of certain antipsychotic medications. It is also used in the formulation of some topical analgesics. Additionally, it has potential applications in the polymer industry for creating specialized materials and in the chemical sensor industry for gas detection.

When handling 4-(4-Isopropyl-1-piperazinyl)phenol (CAS: 67914-97-0), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. It should be handled in a well-ventilated area or under a fume hood. In case of a spill, immediate action should be taken to contain it using absorbent materials and the area should be cleaned with care. Always consult the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.