4,5-Dichloro-3-methylthiophene-2-carboxylic acid(CAS: 854626-34-9)

4,5-Dichloro-3-methylthiophene-2-carboxylic acid is a solid at room temperature with a crystalline form. It has a molecular weight of approximately 228.04 g/mol. The compound is slightly soluble in water and has good solubility in common organic solvents such as ethanol and acetone. It is known for its high reactivity, particularly in nucleophilic substitution and electrophilic aromatic substitution reactions.

4,5-Dichloro-3-methylthiophene-2-carboxylic acid is typically synthesized via the condensation of 3-methylthiophene-2-carboxylic acid with dichloromethane in the presence of a base such as sodium hydride. This method provides high yields and good selectivity. Other synthetic routes include the chlorination of 3-methylthiophene-2-carboxylic acid or the direct chlorination of 3-methylthiophene followed by carboxylation.

4,5-Dichloro-3-methylthiophene-2-carboxylic acid is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in the polymer industry as a monomer for the production of advanced polymers. Additionally, it is used in the sensor technology sector for the development of gas sensors and in the semiconductor industry for various chemical processes.

Proper personal protective equipment (PPE) should be worn when handling 4,5-Dichloro-3-methylthiophene-2-carboxylic acid, including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be cleaned up immediately using appropriate absorbents and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.