2-(4-Bromo-1H-pyrazol-1-yl)pyridine(CAS: 77556-27-5)

2-(4-Bromo-1H-pyrazol-1-yl)pyridine is a crystalline solid with a molecular weight of approximately 246.03 g/mol. It has low solubility in water but is soluble in organic solvents like DMF and DMSO. The compound is moderately reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

2-(4-Bromo-1H-pyrazol-1-yl)pyridine is typically synthesized through a multi-step process involving bromination and coupling reactions. Common methods include the use of bromine in the presence of a base like sodium hydride followed by a coupling step with 2-pyridylamine. High yields and good selectivity can be achieved using appropriate conditions and catalysts.

2-(4-Bromo-1H-pyrazol-1-yl)pyridine is used in various industries, including pharmaceuticals for its potential as a drug candidate, and in organic synthesis as a versatile starting material. It is also used in polymer and sensor applications, where its functional groups enable its use in these areas.

When handling 2-(4-Bromo-1H-pyrazol-1-yl)pyridine, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up with appropriate absorbents and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.