1-Bromo-2-chloro-4-(trifluoromethyl)benzene(CAS: 402-04-0)

1-Bromo-2-chloro-4-(trifluoromethyl)benzene is a clear or colorless liquid with a molecular weight of 265.01 g/mol. It has a low solubility in water (less than 1 g/L) and is highly soluble in organic solvents such as dichloromethane and toluene. The compound is moderately reactive towards nucleophiles and can undergo substitution reactions. It solidifies at -22°C and boils at 100-101°C under 760 mm Hg pressure.

1-Bromo-2-chloro-4-(trifluoromethyl)benzene is typically synthesized via a substitution reaction of 2-chloro-4-(trifluoromethyl)benzene with bromine. The reaction is performed under basic conditions using sodium hydroxide as a catalyst. The yield is around 75-80%, and the product is purified by recrystallization from ethanol or by distillation.

1-Bromo-2-chloro-4-(trifluoromethyl)benzene is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drugs and intermediates. It also finds applications in the polymer industry for the production of fluorinated polymers and in the semiconductor industry for the manufacture of electronic materials. Its trifluoromethyl group makes it useful for its electronic and steric properties.

Proper handling of 1-Bromo-2-chloro-4-(trifluoromethyl)benzene requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be handled with caution, using absorbent materials and properly disposing of the contaminated materials. Always refer to the safety data sheet (SDS) for detailed emergency procedures and storage guidelines.