(5-Chloro-2-thienyl)boronic acid(CAS: 162607-18-3)

(5-Chloro-2-thienyl)boronic acid (CAS: 162607-18-3) is a crystalline solid with a molecular weight of approximately 220.93 g/mol. It has limited solubility in water and good solubility in organic solvents. The compound is moderately reactive, particularly in nucleophilic substitution reactions. It is often used as a boronate ester in organic synthesis and displays good reactivity with phenols and alcohols.

(5-Chloro-2-thienyl)boronic acid (CAS: 162607-18-3) is typically synthesized via the reaction of 2-thiophenecarbaldehyde with boronic acid in the presence of a suitable catalyst, such as Pd(0) and a ligand. The process involves mild conditions and high yields, making it a practical method for industrial and laboratory applications.

(5-Chloro-2-thienyl)boronic acid (CAS: 162607-18-3) is widely used in the pharmaceutical industry for the preparation of chiral compounds and in polymer synthesis for the modification of polymer properties. It also finds applications in the development of sensors and semiconductors due to its unique electronic properties.

When handling (5-Chloro-2-thienyl)boronic acid (CAS: 162607-18-3), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be carefully cleaned up, and appropriate disposal methods should be followed. Always consult the Safety Data Sheet (SDS) for detailed instructions and emergency procedures.