(4S,5R)-2,2-Dimethyl-3-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-phenyl-1,3-oxazolidine-5-carboxylic acid(CAS: 143527-70-2)

(4S,5R)-2,2-Dimethyl-3-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-phenyl-1,3-oxazolidine-5-carboxylic acid is a white crystalline solid with a molecular weight of approximately 404.45 g/mol. It is slightly soluble in water and polar organic solvents. The compound is reactive towards nucleophiles and can undergo esterification and amide formation. It has a pKa of around 3.5 and is stable under normal conditions but should be stored away from moisture and heat.

(4S,5R)-2,2-Dimethyl-3-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-phenyl-1,3-oxazolidine-5-carboxylic acid can be synthesized through multi-step reactions. Common methods include esterification of a 2-(2-methyl-2-propanyloxy)acetic acid derivative with a phenylalanine derivative. The reaction typically uses a catalytic amount of a Lewis acid like aluminum chloride, and the yield is around 70-80% with good selectivity.

(4S,5R)-2,2-Dimethyl-3-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-phenyl-1,3-oxazolidine-5-carboxylic acid is used in the pharmaceutical industry for the synthesis of drug intermediates. It is also applicable in the polymer industry for the development of special polymers and in the sensor industry for the fabrication of sensitive materials. Additionally, it can be used in the semiconductor industry for developing photoresists and other electronic materials.

When handling (4S,5R)-2,2-Dimethyl-3-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-phenyl-1,3-oxazolidine-5-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be performed in a well-ventilated area, preferably in a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials and disposal methods. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.