O-Phosphonothreonine(CAS: 1114-81-4)

O-Phosphonothreonine (CAS: 1114-81-4) is a crystalline solid with a molecular weight of approximately 187.15 g/mol. It is slightly soluble in water and has poor solubility in common organic solvents. Chemically, it exhibits typical reactivity for phosphonic acid derivatives, making it susceptible to nucleophilic substitution and hydrolysis under basic conditions.

O-Phosphonothreonine (CAS: 1114-81-4) is typically synthesized through the phosphoramidation of threonine using phosphorus oxychloride and a base catalyst. The reaction is selective and yields a product with high purity. The process requires careful temperature control to ensure optimal yield and selectivity.

O-Phosphonothreonine (CAS: 1114-81-4) finds applications in pharmaceuticals, particularly in the development of nucleoside analogs and antiviral drugs. It is also used in the synthesis of certain polymers and as a reagent in biochemical assays.

When handling O-Phosphonothreonine (CAS: 1114-81-4), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a fume hood and handled in a well-ventilated area to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be neutralized with a suitable solution. Safety Data Sheets (SDS) should be consulted for detailed safety information.