5,7-Difluoro-2,3-dihydro-4H-chromen-4-one(CAS: 844648-22-2)

5,7-Difluoro-2,3-dihydro-4H-chromen-4-one is a crystalline solid with a molecular weight of approximately 220.05 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards bases and can undergo various transformations such as hydrolysis. It has a melting point of about 118-120°C.

5,7-Difluoro-2,3-dihydro-4H-chromen-4-one is commonly synthesized via the condensation of 1,3-diketones with fluorinated diols using a suitable catalyst such as a metal catalyst. The reaction is typically highly selective, yielding a high yield of product. The exact synthesis method may vary depending on the starting materials and conditions.

5,7-Difluoro-2,3-dihydro-4H-chromen-4-one is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring chromenone skeletons. It has also found applications in the polymer industry for the modification of polymer properties and in the production of sensors and semiconductors due to its optical and electronic properties.

When handling 5,7-Difluoro-2,3-dihydro-4H-chromen-4-one, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a fume hood to avoid inhalation of vapors. Spills should be contained and disposed of according to safety data sheet (SDS) guidelines. Always refer to the latest SDS for detailed handling instructions.