4-Chloro-7-hydroxy-1-indanone(CAS: 81945-10-0)

4-Chloro-7-hydroxy-1-indanone is a yellow crystalline solid with a molecular weight of 220.59 g/mol. It is slightly soluble in water and ethanol. Reactivity is moderate, with typical reactions being substitution and addition. It is stable under normal conditions but should be stored away from strong oxidizing agents to prevent unwanted reactions.

4-Chloro-7-hydroxy-1-indanone can be synthesized via a multi-step process. Common methods include the reaction of 7-hydroxy-1-indanone with thionyl chloride followed by dehydration. The reaction is typically conducted in anhydrous conditions under mild heating, with selective formation of the desired chlorinated product with high yield.

4-Chloro-7-hydroxy-1-indanone finds applications in various industries. It is used in the pharmaceutical sector as an intermediate for drug synthesis. In the polymer industry, it serves as a monomer for the preparation of specific polymers. Additionally, it is utilized in the production of sensors and semiconductor materials due to its unique chemical properties.

Handle 4-Chloro-7-hydroxy-1-indanone with caution, wearing appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure proper ventilation in the laboratory by using a fume hood. Store it in a cool, dry place, away from direct sunlight and heat sources. In case of spill, neutralize with an appropriate reagent and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.