1-(4-Fluorophenyl)acetone(CAS: 459-03-0)

1-(4-Fluorophenyl)acetone (CAS: 459-03-0) is a colorless to yellow liquid. It has a molecular weight of approximately 163.15 g/mol and a melting point of -21°C. The compound is moderately soluble in water but highly soluble in organic solvents. It exhibits good reactivity, particularly with nucleophiles and hydrogen acceptors, making it a versatile intermediate in synthetic chemistry.

1-(4-Fluorophenyl)acetone can be synthesized by the reaction of 4-fluorophenol with acetic anhydride. This process is catalyzed by an acid, such as concentrated sulfuric acid, and typically yields a product with a yield of around 85%. The reaction is known for its good selectivity and efficiency.

1-(4-Fluorophenyl)acetone (CAS: 459-03-0) is used extensively in the pharmaceutical industry for the synthesis of various active pharmaceutical ingredients. It also finds applications in the production of polymers, sensors, and semiconductors due to its functional groups that facilitate cross-linking and electronic properties.

When handling 1-(4-Fluorophenyl)acetone (CAS: 459-03-0), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents, and the material safety data sheet (MSDS) should always be consulted for detailed safety guidelines.