ABT-418 hydrochloride(CAS: 147388-83-8)

ABT-418 hydrochloride is a white crystalline powder with a molecular weight of approximately 609.54 g/mol. It has a solubility of about 1 mg/mL in water and is relatively stable under normal conditions. However, it reacts with bases to form the free base and is slightly soluble in organic solvents such as ethanol and methanol.

ABT-418 hydrochloride is synthesized through a multi-step process involving the condensation of 2-aminobenzamide with 1-(4-(trifluoromethyl)phenyl)-4-(4-(trifluoromethyl)phenyl)-1H-imidazole-5-carboxylic acid. The synthesis typically involves the use of coupling agents and protecting groups, with yields around 50-60%.

ABT-418 hydrochloride is primarily used in the pharmaceutical industry for research purposes. It has shown potential as an inhibitor of the IKB kinase (IKK) and is being investigated for its therapeutic effects in various inflammatory and immunological diseases.

When handling ABT-418 hydrochloride, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work must be conducted in a well-ventilated area or a fume hood. In case of a spill, it should be carefully cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed. Refer to the Safety Data Sheet (SDS) for detailed safety information.