Methyl chloro(oxo)acetate(CAS: 5781-53-3)

Methyl chloro(oxo)acetate (CAS: 5781-53-3) is a colorless to slightly yellow liquid with a molecular weight of approximately 117.5 g/mol. It has a high solubility in organic solvents but is only slightly soluble in water. This compound is known for its reactivity, particularly in nucleophilic substitution reactions. It is also a potent acid and can react with basic compounds.

Methyl chloro(oxo)acetate (CAS: 5781-53-3) is typically synthesized through the reaction of methyl acetate with phosphorus oxychloride under anhydrous conditions. This process involves the use of a Lewis acid catalyst to facilitate the substitution reaction, yielding a high yield and selectivity for the desired product.

Methyl chloro(oxo)acetate (CAS: 5781-53-3) is primarily used in the pharmaceutical industry for the synthesis of certain intermediates and in the production of other chemicals. It is also used in the polymer industry for the modification of polymers and in the sensor industry for the development of chemical sensors.

When handling Methyl chloro(oxo)acetate (CAS: 5781-53-3), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the use of a fume hood to minimize exposure. Handle the compound with care as it is corrosive and can cause skin and eye irritation. In case of a spill, immediately contain the spill and clean up using appropriate absorbents as per the Safety Data Sheet (SDS).