(2-Chloroethoxy)acetic acid(CAS: 14869-41-1)

(2-Chloroethoxy)acetic acid is a colorless or white crystalline solid with a molecular weight of approximately 161.58 g/mol. It has a pKa of about 2.3 and is slightly soluble in water. This compound is reactive, particularly towards nucleophiles and bases. It is used in various chemical reactions due to its acidic and chloroalkoxy functionalities.

(2-Chloroethoxy)acetic acid can be synthesized by the reaction of chloroacetic acid with ethylene oxide, followed by hydrolysis. Commonly, this involves treating chloroacetic acid with ethylene oxide in the presence of a catalyst like sulfuric acid. The yield is typically around 80-90%, with the product being isolated by crystallization.

(2-Chloroethoxy)acetic acid is used in pharmaceuticals for the synthesis of certain drugs, as well as in the production of polymers and sensors. It is also utilized in the preparation of organochlorine compounds and as a reagent in analytical chemistry for developing detection methods in semiconductors.

When handling (2-Chloroethoxy)acetic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. This compound should be stored in a cool, dry place, away from direct sunlight and heat sources. Use a fume hood for all handling to avoid inhalation. In case of a spill, contain the material and clean up according to the Material Safety Data Sheet (MSDS). Always consult the latest SDS for specific safety guidelines.