(6alpha,11beta,16alpha)-9-Chloro-6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione(CAS: 4828-27-7)

(6alpha,11beta,16alpha)-9-Chloro-6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione is a crystalline compound with a molecular weight of approximately 402.14 g/mol. It is sparingly soluble in water but highly soluble in organic solvents. The compound exhibits moderate reactivity, particularly in acidic and basic conditions. It has a melting point around 175-178°C and is stable under normal laboratory conditions.

This compound can be synthesized through a series of reactions including alkylation, chlorination, and hydroxylation of precursor steroids. Commonly, the synthesis involves the use of catalytic hydrogenation and halogenation steps. The overall yield is around 70%, and the selectivity is high, ensuring the desired stereochemistry. This process typically requires the use of specialized organic solvents and precise temperature control.

This compound is primarily used in the pharmaceutical industry for the development of hormonal drugs. It also has applications in the production of certain agricultural chemicals and as a precursor in the synthesis of other organic compounds. Additionally, it may be utilized in the polymer industry for specific applications requiring unique chemical properties.

Handling (6alpha,11beta,16alpha)-9-Chloro-6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione requires the use of personal protective equipment (PPE) including gloves, goggles, and a lab coat. Ensure the work is conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and proper disposal methods. Always consult the Safety Data Sheet (SDS) for specific handling guidelines and safety information.