1,2-oxazole-3-carboxylic acid(CAS: 3209-71-0)

1,2-Oxazole-3-carboxylic acid is a crystalline solid with a molecular weight of approximately 125.11 g/mol. It is slightly soluble in water but soluble in organic solvents. The compound is reactive towards nucleophiles and can undergo condensation reactions. It has a pKa of about 7.2, indicating weak acidity.

1,2-Oxazole-3-carboxylic acid can be synthesized through the condensation of 3-amino-1,2-oxazole with formic acid. Other methods include the reaction of 1,2-oxazole with chloroacetic acid or carboxylation of 1,2-oxazol-3-yl methanol. These methods provide good yield and selectivity.

1,2-Oxazole-3-carboxylic acid is used in the pharmaceutical industry for the synthesis of biologically active compounds. It is also utilized in the production of polymers, particularly in the development of ionomers and in the manufacturing of sensors for detecting various gases and chemicals.

When handling 1,2-oxazole-3-carboxylic acid, wear protective gloves and goggles. Work in a well-ventilated area or a fume hood. In case of spill, use appropriate absorbent material and dispose of it according to local regulations. Always refer to the safety data sheet (SDS) for detailed safety and handling information.