Methyl 2-aminoisonicotinate(CAS: 6937-03-7)

Methyl 2-aminoisonicotinate (CAS: 6937-03-7) is a crystalline compound with a molecular weight of approximately 189.22 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. The compound has a pKa of 2.5, indicating its acidic nature, and it is reactive, particularly towards nucleophilic substitution reactions at the amide group.

Methyl 2-aminoisonicotinate (CAS: 6937-03-7) can be synthesized through the reaction of nicotinic acid with methylamine. The process typically involves heating the mixture of nicotinic acid and methylamine in an alcoholic solvent under basic conditions. This method provides a yield of around 85%, with the use of sodium hydroxide as a catalyst to enhance reactivity and selectivity.

Methyl 2-aminoisonicotinate (CAS: 6937-03-7) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the polymer industry as a crosslinking agent and in the development of sensors and semiconductors due to its functional amide group.

When handling Methyl 2-aminoisonicotinate (CAS: 6937-03-7), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Due to its acidic nature, it is advisable to work in a fume hood to minimize inhalation risk. In case of a spill, neutralize the acid with a base and dispose of the waste according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.