2-(Chloromethyl)pyrimidine hydrochloride(CAS: 936643-80-0)

2-(Chloromethyl)pyrimidine hydrochloride is a white crystalline solid with a molecular weight of approximately 235.56 g/mol. It has a solubility in water of 20 g/L at 25°C. The compound is moderately reactive, particularly towards nucleophiles and reducing agents. It is sparingly soluble in common organic solvents like ethanol and acetone.

2-(Chloromethyl)pyrimidine hydrochloride can be synthesized via the reaction of 2-chloromethylpyrimidine with hydrochloric acid. The synthesis is typically carried out in anhydrous conditions to avoid hydrolysis. The yield is around 85%, with high selectivity towards the desired product.

2-(Chloromethyl)pyrimidine hydrochloride is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for preparing certain types of resins and coatings. Additionally, it is used in the development of organic sensors and some semiconductor materials.

When handling 2-(Chloromethyl)pyrimidine hydrochloride, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat is essential. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.