3'-Deoxy-3'-fluoroguanosine(CAS: 123402-21-1)

3'-Deoxy-3'-fluoroguanosine (CAS: 123402-21-1) is a white to off-white crystalline powder with a molecular weight of approximately 318.12 g/mol. It is slightly soluble in water and ethanol. The compound exhibits moderate reactivity, particularly in the presence of nucleases, which can lead to degradation. It is stable under acidic and basic conditions but is sensitive to heat and light.

3'-Deoxy-3'-fluoroguanosine (CAS: 123402-21-1) is typically synthesized by fluorination of deoxyguanosine followed by deprotection of the 3'-hydroxyl group. Commonly used fluorinating agents include N-fluorobenzenesulfonate (NFSO3F) and N-fluoropropylsulfonate (NFPS). The reaction is typically performed in the presence of a solvent such as dichloromethane or acetonitrile. The product is then purified by recrystallization or chromatography.

3'-Deoxy-3'-fluoroguanosine (CAS: 123402-21-1) is primarily used in the pharmaceutical industry. It serves as a building block for the synthesis of nucleoside analogs used in antiviral and anticancer therapies. It may also find applications in polymer synthesis and as a component in certain sensors and semiconductors, although its use in these areas is less common.

When handling 3'-Deoxy-3'-fluoroguanosine (CAS: 123402-21-1), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored under nitrogen to prevent oxidation and degradation. It should be kept away from heat and light sources. In case of a spill, it should be cleaned up promptly using appropriate absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.