7-Bromo-1H-indole(CAS: 51417-51-7)

7-Bromo-1H-indole (CAS: 51417-51-7) is a crystalline solid with a molecular weight of approximately 204.03 g/mol. It has a low solubility in water but is more soluble in organic solvents. This compound exhibits good stability under normal conditions but can react with strong bases. It is not typically flammable but should be handled with care due to its potential reactivity.

7-Bromo-1H-indole (CAS: 51417-51-7) can be synthesized via bromination of 1H-indole using N-bromosuccinimide (NBS) in an aryl halide reaction. This process involves the use of a radical initiator to generate bromine radicals, which then attack the indole ring. The reaction yields a high selectivity for the bromo substitution, with good yield under appropriate conditions.

7-Bromo-1H-indole (CAS: 51417-51-7) finds application in the pharmaceutical industry for the development of new drug candidates. It also serves as a precursor in the synthesis of certain polymers and can be used in the preparation of sensors and semiconductors due to its unique chemical properties.

When handling 7-Bromo-1H-indole (CAS: 51417-51-7), it is essential to use appropriate personal protective equipment (PPE) such as gloves and goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbent materials, and disposal should follow local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.