2-(4-Bromophenyl)-1,3-oxazole(CAS: 176961-50-5)

2-(4-Bromophenyl)-1,3-oxazole is a white crystalline solid with a molecular weight of approximately 237.02 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong reducing agents. It is used in various organic syntheses and pharmaceutical applications.

2-(4-Bromophenyl)-1,3-oxazole can be synthesized via a multistep process where a bromophenol reacts with carbon dioxide in the presence of a base like sodium hydride. This method yields a high purity product with good selectivity and yield. Other routes involve treating bromobenzene with a suitable oxazoline precursor under controlled conditions.

2-(4-Bromophenyl)-1,3-oxazole is primarily used in the pharmaceutical industry for the synthesis of various drugs. It also finds applications in the polymer industry for developing new materials with specific properties. Additionally, it is used in the chemical sensor industry for detecting certain gases and in semiconductor manufacturing for etching and cleaning processes.

When handling 2-(4-Bromophenyl)-1,3-oxazole, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handle in a well-ventilated area or fume hood to avoid inhalation. In case of a spill, immediately clean up using appropriate procedures and dispose of materials in accordance with local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.