6-Chloro-1H-pyrrolo[3,2-b]pyridine(CAS: 1021339-19-4)

6-Chloro-1H-pyrrolo[3,2-b]pyridine is a crystalline solid with a molecular weight of approximately 182.01 g/mol. It is slightly soluble in water but has good solubility in organic solvents like methanol and ethanol. Chemically, it is stable under normal conditions but can react with nucleophiles. It has a pKa of about 4.5 and exhibits basicity due to the presence of a pyridine ring.

6-Chloro-1H-pyrrolo[3,2-b]pyridine is synthesized via the condensation of 1H-pyrrolo[3,2-b]pyridine with thionyl chloride followed by purification. Alternatively, it can be obtained by chlorination of 1H-pyrrolo[3,2-b]pyridine using phosphorus trichloride as a catalyst. The yield is typically around 75-80%, and the reaction involves electrophilic aromatic substitution.

6-Chloro-1H-pyrrolo[3,2-b]pyridine is used in the pharmaceutical industry for its potential as a drug candidate, particularly in the development of anti-inflammatory and antiviral agents. It is also utilized in the sensor industry for its sensing properties and in the semiconductor industry for its use in certain electronic compounds.

Proper personal protective equipment (PPE) is required when handling 6-Chloro-1H-pyrrolo[3,2-b]pyridine. Wearing goggles, gloves, and a lab coat is essential to prevent skin contact and eye exposure. Work in a fume hood to avoid inhalation. Spills should be cleaned up carefully, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.