4-Fluoro-1,3-benzoxazol-2(3H)-one(CAS: 590422-12-1)

4-Fluoro-1,3-benzoxazol-2(3H)-one (CAS 590422-12-1) is a crystalline solid with a molecular weight of approximately 187.12 g/mol. It has a solubility of about 1.2 g/L in water and is soluble in common organic solvents like DMSO and acetonitrile. This compound is relatively stable but can react with strong bases. It is used as an intermediate in the synthesis of various pharmaceuticals and functional polymers.

4-Fluoro-1,3-benzoxazol-2(3H)-one (CAS 590422-12-1) can be synthesized via the condensation of 4-fluorobenzaldehyde with urea followed by ring closure. The reaction typically requires a condensing agent like hydroxylamine hydrochloride or phthalimide. The yield is generally around 75-80%, and the method is selective, producing the desired product with high purity.

4-Fluoro-1,3-benzoxazol-2(3H)-one (CAS 590422-12-1) is primarily used in the pharmaceutical and polymer industries. It serves as an intermediate in the synthesis of various drugs and also finds applications in the development of functional polymers and sensors. Additionally, it is sometimes used in semiconductor manufacturing processes.

When handling 4-Fluoro-1,3-benzoxazol-2(3H)-one (CAS 590422-12-1), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be worked with in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. For detailed safety information, refer to the Safety Data Sheet (SDS).