7-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(CAS: 53841-99-9)

7-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one is a crystalline white to off-white solid with a molecular weight of approximately 275.05 g/mol. It has low solubility in water but is more soluble in organic solvents like dichloromethane and ethanol. This compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions at the bromine atom.

7-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one is often synthesized via bromination of 1,3,4,5-tetrahydro-2H-1-benzazepin-2-one followed by the introduction of a bromine atom. Commonly, this is achieved using N-bromosuccinimide (NBS) in an organic solvent like dichloromethane under light or heat conditions. The reaction yields a mixture that can be purified through recrystallization from a suitable solvent.

7-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one is used in pharmaceuticals for the synthesis of various medicinal compounds. It also finds applications in the development of sensors for chemical detection and in the production of certain polymers. Additionally, it can be used in the synthesis of materials for semiconductors.

When handling 7-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and goggles. The compound should be used in a well-ventilated area or under a fume hood to prevent inhalation. In the event of a spill, immediately clean up the area and consult the Safety Data Sheet (SDS) for specific spill cleanup procedures. Proper disposal should follow local regulations and guidelines.