Ethylmalonic acid(CAS: 601-75-2)

Ethylmalonic acid (CAS: 601-75-2) is a colorless, crystalline solid with a molecular weight of 124.10 g/mol. It has a pKa of 2.7 and is highly soluble in water. The compound is moderately reactive, particularly with bases and reducing agents. It is a key intermediate in organic synthesis and is used in the preparation of other chemicals.

Ethylmalonic acid is commonly synthesized through the hydration of ethylacetoacetate. This process involves the use of a catalyst such as sulfuric acid or phosphoric acid. The synthesis typically yields a mixture of isomers, but purification methods can be employed to achieve higher selectivity and yield. The reaction is exothermic and requires careful temperature control.

Ethylmalonic acid (CAS: 601-75-2) is widely used in the pharmaceutical industry for the synthesis of drugs, as a reagent in organic synthesis, and in the production of various polymers. It is also utilized in the development of sensors and as a precursor in semiconductor manufacturing processes.

When handling Ethylmalonic acid (CAS: 601-75-2), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.