4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol(CAS: 779331-49-6)

4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is a white to off-white solid with a melting point of 108-110°C. Its molecular weight is approximately 319.2 g/mol. It is slightly soluble in water but soluble in polar organic solvents. Chemically, it is stable but can react with strong acids and bases. It is used in organic synthesis as a boron-fluorine-containing compound.

4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol can be synthesized via a reaction of 4-fluoro-2-hydroxybenzene with 1,3-bis(diphenylphosphino)propane and palladium(II) acetate in the presence of triphenylphosphine. The yield is typically around 85%, and the reaction is highly selective.

4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is primarily used in the pharmaceutical industry for the synthesis of biologically active compounds. It is also utilized in the polymer industry for the preparation of functionalized polymers, and in the sensing and semiconductor industries for the development of advanced materials.

When handling 4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Ensure the use of a fume hood during synthesis and storage. In case of spill, use appropriate spill cleanup kits. Refer to the Safety Data Sheet (SDS) for detailed information on handling and emergency procedures.