3-Bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine(CAS: 90914-41-3)

3-Bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine is a crystalline solid with a molecular weight of approximately 252.03 g/mol. It has a very low aqueous solubility but is more soluble in organic solvents like DMSO and DMF. This compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions.

3-Bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine is synthesized through a multistep process involving the protection of the pyrimidine ring, followed by bromination and chlorination. This compound is often prepared using reagents like bromine and chlorine in the presence of catalysts such as N-iodosuccinimide (NIS) for selective halogenation.

3-Bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine finds applications in the pharmaceutical industry, particularly in the synthesis of bioactive compounds and as a precursor for drug candidates. It is also used in the polymer industry for the development of functional materials and in sensor technology for detecting specific chemical species.

When handling 3-Bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. Store it in a cool, dry place away from direct sunlight and flammable materials. Use a fume hood during preparation and disposal, and follow the safety data sheet (SDS) for proper spill handling and disposal procedures.