6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione(CAS: 37795-77-0)

6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione is a white crystalline solid with a molecular weight of approximately 215.21 g/mol. It has a solubility of about 2.5 g/100 mL in water and is soluble in common organic solvents. This compound is moderately reactive, particularly towards nucleophiles and bases, making it useful in various synthesis reactions.

6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione can be synthesized via a multi-step process involving the condensation of methoxybenzaldehyde and urea. This reaction is typically catalyzed by a strong acid and conducted at room temperature. The overall yield is around 75%, with good regioselectivity and stereoselectivity.

6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry to enhance certain properties of polymers. Additionally, it finds applications in the production of sensors and as a reagent in organic synthesis.

When handling 6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione, it is essential to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. The compound should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.