2,4-Dichloro-5-fluorobenzoic acid(CAS: 86522-89-6)

2,4-Dichloro-5-fluorobenzoic acid (CAS: 86522-89-6) is a crystalline solid with a molecular weight of approximately 220.02 g/mol. It has a melting point of 228-230°C and is slightly soluble in water, with a solubility of about 0.5 g/L at 25°C. The compound is known for its reactivity, particularly towards nucleophilic substitution and electrophilic aromatic substitution reactions.

2,4-Dichloro-5-fluorobenzoic acid is typically synthesized by the reaction of 4-chloro-5-fluorobenzoic acid with chlorine gas. The reaction involves chlorination at the 2-position, followed by the removal of the hydrogen from the carboxylic acid group to form the acid chloride intermediate, which is then hydrolyzed to yield the desired product. The use of aluminum chloride as a catalyst can improve the selectivity and yield of the reaction.

2,4-Dichloro-5-fluorobenzoic acid is primarily used in the pharmaceutical and chemical industries. It serves as an intermediate in the synthesis of various drugs and organic compounds. Additionally, it is utilized in the production of certain analytical reagents and as a component in the development of sensors and semiconductors.

When handling 2,4-Dichloro-5-fluorobenzoic acid (CAS: 86522-89-6), appropriate personal protective equipment (PPE) should be used, including gloves, goggles, and a laboratory coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spills, they should be properly contained and disposed of according to safety data sheet (SDS) guidelines. Always ensure adequate ventilation and handle the compound in a well-ventilated fume hood to minimize inhalation risks.