3-ethoxyprop-2-enoyl chloride(CAS: 99471-66-6)

3-ethoxyprop-2-enoyl chloride is a liquid with a molecular weight of approximately 142.17 g/mol. It has a specific gravity of about 1.11 g/cm³ and is only slightly soluble in water. It is highly reactive due to the presence of a reactive acylium ion and easily undergoes nucleophilic addition reactions. It is also prone to hydrolysis under basic conditions.

3-ethoxyprop-2-enoyl chloride is typically synthesized via the reaction of 3-ethoxyprop-2-enol with thionyl chloride. The process involves the dehydration of the alcohol to form the enol, which then reacts with thionyl chloride to produce the chloride. This method provides good yield and selectivity under mild conditions.

3-ethoxyprop-2-enoyl chloride finds application in various industries, including pharmaceuticals, where it is used as an intermediate in drug synthesis; in polymers for its ability to enhance certain properties; and in sensors and semiconductors for its reactivity and functionality.

When handling 3-ethoxyprop-2-enoyl chloride, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be neutralized with an appropriate base and the area should be thoroughly rinsed. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and recommended procedures.