(1Z)-2-[(Dimethoxyphosphorothioyl)sulfanyl]-N-methylethanimidic acid(CAS: 60-51-5)

(1Z)-2-[(Dimethoxyphosphorothioyl)sulfanyl]-N-methylethanimidic acid (CAS: 60-51-5) is a white crystalline solid with a molecular weight of approximately 296.27 g/mol. It has a low solubility in water but is more soluble in organic solvents. This compound is highly reactive, particularly towards nucleophiles. It is used in the synthesis of various phosphorothioates and as a reagent in organic chemistry.

This compound is typically synthesized via the reaction of dimethoxyphosphorodithioic acid with ethanamine. The method involves the nucleophilic substitution of ethanamine on the phosphorus atom, followed by methylation to form the N-methyl derivative. The reaction is generally carried out in polar aprotic solvents under ambient conditions.

This compound is primarily used in the pharmaceutical industry for the synthesis of phosphorothioate analogs of nucleotides and nucleic acids. It is also utilized in the semiconductor industry for specific applications requiring phosphorus-containing compounds. Additionally, it has potential applications in sensor technology.

When handling (1Z)-2-[(Dimethoxyphosphorothioyl)sulfanyl]-N-methylethanimidic acid (CAS: 60-51-5), it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Handle in a well-ventilated area or a fume hood. Spills should be cleaned up immediately and handled according to the Material Safety Data Sheet (MSDS) guidelines. Ensure proper storage in a cool, dry place away from incompatible materials.