5-Pyrimidinylboronic acid(CAS: 109299-78-7)

5-Pyrimidinylboronic acid is a solid compound with a crystalline form. Its molecular weight is approximately 198.17 g/mol. It has a low solubility in water but good solubility in organic solvents like ethanol and acetonitrile. Chemically, it shows reactivity towards nucleophiles and can undergo boronate ester formation under mild conditions. It is stable under normal conditions but should be stored in a dry, cool place away from direct sunlight.

5-Pyrimidinylboronic acid is typically synthesized via a reaction between 5-pyrimidinylamine and triphenylphosphine in the presence of boron tribromide. This method provides a high yield and good selectivity. The reaction is performed under anhydrous conditions to prevent side reactions. Other methods include direct synthesis from 5-pyrimidinecarboxylic acid through arylboronic acid coupling reactions.

5-Pyrimidinylboronic acid is used in various industries, particularly in pharmaceuticals and polymer chemistry. In pharmaceuticals, it serves as a key intermediate in the synthesis of drugs. In polymer chemistry, it acts as a monomer for preparing functional polymers. Additionally, it finds applications in sensor technology and as a building block in semiconductor materials.

When handling 5-Pyrimidinylboronic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation of dust or vapors. Spills should be cleaned up using appropriate materials, and the area should be thoroughly washed down. Always follow the safety data sheet (SDS) for detailed safety information and proper disposal methods. Storage should be in a cool, dry place away from incompatible materials.