1-Methyl-4-nitro-1H-pyrazole(CAS: 82208-47-7)

1-Methyl-4-nitro-1H-pyrazole is a crystalline solid with a molecular weight of approximately 168.08 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can undergo nitro group reduction under basic conditions. Its melting point is around 142-144°C.

1-Methyl-4-nitro-1H-pyrazole is commonly synthesized via the nitration of 1-methyl-1H-pyrazole. The nitration reaction can be achieved using fuming nitric acid in the presence of sulfuric acid as a catalyst. The yield is typically around 85-90%, and the product is isolated by recrystallization from ethanol.

1-Methyl-4-nitro-1H-pyrazole is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly those involving nitro groups. It also finds applications in the production of dyes, polymers, and as a starting material for sensor development. Its use in semiconductors is less common but possible due to its electronic properties.

When handling 1-Methyl-4-nitro-1H-pyrazole, it is crucial to wear appropriate personal protective equipment, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled with caution using appropriate absorbents, and the area should be cleaned thoroughly. Always consult the Safety Data Sheet (SDS) for detailed safety information.