(3S)-1,3-Butanediol(CAS: 24621-61-2)

(3S)-1,3-Butanediol is a colorless liquid with a slightly sweet taste. It has a molecular weight of approximately 88.09 g/mol and a boiling point of 126.5°C. The compound is slightly soluble in water but miscible with many organic solvents. It is less reactive than its isomer, (3R)-1,3-butanediol, and can undergo condensation reactions and reduction processes, making it useful in various chemical applications.

(3S)-1,3-Butanediol is commonly synthesized via hydrogenation of 1,3-butenedione catalyzed by palladium-based catalysts. The process yields a mixture of (3S) and (3R) isomers, with the (3S) isomer being the more preferred. Other methods include enzymatic reduction of ketones or racemic 1,3-Butanediol, which can be resolved to obtain the (3S) isomer with high enantiomeric excess.

(3S)-1,3-Butanediol is widely used in the pharmaceutical, polymer, and sensor industries. In the pharmaceutical sector, it is used as a precursor for the synthesis of certain drugs. In polymers, it serves as a monomer for the production of polyurethane and other thermoplastics. Additionally, its hydroxyl groups make it suitable for use in the development of sensors and semiconductors.

When handling (3S)-1,3-Butanediol, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats to prevent skin contact and eye irritation. Work in a well-ventilated area or a fume hood to avoid inhalation. In case of skin contact, wash the affected area with soap and water. For spills, absorb with an appropriate material and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for specific safety information and emergency procedures.