4-Chloro-2-butanone(CAS: 6322-49-2)

4-Chloro-2-butanone is a colorless or slightly yellow liquid with a pungent odor. It has a molecular weight of approximately 123.57 g/mol and a boiling point of 106.5°C. The compound is slightly soluble in water but miscible with most organic solvents. It is moderately reactive with bases and can undergo nucleophilic substitution reactions.

4-Chloro-2-butanone can be synthesized via the acetylation of 2-chlorobutane followed by dehydration. Alternatively, it can be prepared by the chlorination of 2-butanone. Commonly, the reaction involves the use of phthalic anhydride as a catalyst and provides a yield of around 85-90%.

4-Chloro-2-butanone is used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also utilized in the polymer industry for the production of plasticizers and in the chemical sensors industry for detecting certain gases. Additionally, it plays a role in the semiconductor industry as a cleaning agent.

4-Chloro-2-butanone should be handled in a well-ventilated area and with proper Personal Protective Equipment (PPE) such as gloves and safety goggles. It is important to use a fume hood during handling to avoid inhalation. In case of a spill, it should be cleaned up using appropriate procedures, and the site should be properly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information.