4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol(CAS: 779331-28-1)

4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is a white crystalline solid with a molecular weight of approximately 315.02 g/mol. It has low solubility in water but is soluble in organic solvents such as ethanol and dichloromethane. Chemically, it is stable under normal conditions but can react with strong bases. It is used in organic synthesis and has potential applications in pharmaceuticals and materials science.

4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is typically synthesized through a boronate ester formation reaction. The process involves the reaction of 4-chlorophenol with tetramethyl-1,3,2-dioxaborolane in the presence of a base such as potassium carbonate and a palladium catalyst. The reaction yield is generally high, and the product is isolated by filtration and purification techniques.

4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is used in various industries, including pharmaceuticals, where it serves as a precursor for drug synthesis. It also finds applications in the production of organic materials and as a reagent in polymer synthesis. Additionally, it has potential uses in the development of sensors and semiconductors.

When handling 4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, it is essential to use personal protective equipment (PPE) including gloves and safety goggles. Work should be carried out in a well-ventilated area or a fume hood to minimize inhalation exposure. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.