5,6,7,8-Tetrahydro-1,6-naphthyridin-2(3H)-one(CAS: 676994-64-2)

5,6,7,8-Tetrahydro-1,6-naphthyridin-2(3H)-one is a crystalline solid with a molecular weight of approximately 212.23 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and dimethylformamide. This compound exhibits moderate reactivity, particularly towards nucleophiles and electrophiles. It is stable under normal conditions but should be handled in a fume hood to avoid inhalation exposure.

5,6,7,8-Tetrahydro-1,6-naphthyridin-2(3H)-one is synthesized via the ring-closure of 3-aminopyridine with ethylene oxide. The reaction typically involves a base like sodium hydroxide. The product is isolated by filtration and recrystallization. The method yields up to 85% product purity with good selectivity.

5,6,7,8-Tetrahydro-1,6-naphthyridin-2(3H)-one finds applications in pharmaceuticals, where it serves as an intermediate in the synthesis of various drug candidates. It is also used in the development of sensors and as a building block in polymer chemistry for its unique electronic properties.

When handling 5,6,7,8-Tetrahydro-1,6-naphthyridin-2(3H)-one, it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work in a well-ventilated area or a fume hood to avoid inhalation exposure. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed emergency response procedures.