Tacrolimus monohydrate(CAS: 109581-93-3)

Tacrolimus monohydrate is a water-soluble form of the immunosuppressive drug tacrolimus, used in organ transplant rejection prevention and other autoimmune conditions. Its chemical formula is C41H56N6O14·H2O. It is characterized by its high water solubility, making it more convenient for formulation and administration compared to its anhydrous form.

Tacrolimus monohydrate is primarily used as an immunosuppressant in organ transplants to prevent rejection. It is also utilized in the treatment of severe transplant rejection, and in dermatology for treating atopic dermatitis. Its immunosuppressive properties make it valuable in managing autoimmune diseases and inflammatory conditions.

Tacrolimus monohydrate can have side effects, including nephrotoxicity, hypertension, and hyperlipidemia. It is classified as a category C drug in pregnancy, indicating potential risks. Proper handling and storage are essential, and healthcare providers must monitor patients for adverse reactions. Safe handling includes wearing gloves and goggles, and storing under controlled conditions to minimize risk.

Tacrolimus monohydrate should be stored in a tightly closed container at room temperature (15-30°C) and away from direct light. It should be kept in a dry place to prevent moisture absorption, which can affect its solubility. Avoiding high humidity and heat is crucial for maintaining its stability and potency. Proper storage helps ensure its effectiveness and safety when administered.