Ethyl (1E)-N-cyanoethanimidate(CAS: 1558-82-3)

Ethyl (1E)-N-cyanoethanimidate (CAS: 1558-82-3) is a crystalline solid with a molecular weight of approximately 126.12. It has a high solubility in polar solvents like methanol and ethanol but is less soluble in water. The compound is known for its reactivity, particularly in nucleophilic substitution and condensation reactions. It is also susceptible to hydrolysis in the presence of moisture.

Ethyl (1E)-N-cyanoethanimidate (CAS: 1558-82-3) can be synthesized through the reaction of ethyl acetoacetate with cyanoacetic acid in the presence of a catalytic amount of a Lewis acid such as aluminum chloride. The reaction is carried out at room temperature, and the yield is typically around 70-80%. Other methods involve the condensation of ethyl acetoacetate with cyanuric chloride, which provides good selectivity and yield.

Ethyl (1E)-N-cyanoethanimidate (CAS: 1558-82-3) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It also finds applications in the polymer industry for the modification of polymers, in the sensor industry for developing gas sensors, and in the semiconductor industry for the production of organic semiconductors.

When handling Ethyl (1E)-N-cyanoethanimidate (CAS: 1558-82-3), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be cleaned up with appropriate absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.