7-Fluoro-2,3-dihydro-4H-chromen-4-one(CAS: 113209-68-0)

7-Fluoro-2,3-dihydro-4H-chromen-4-one is a white to off-white crystalline powder with a molecular weight of approximately 220.07 g/mol. It has low solubility in water but is more soluble in organic solvents like methanol and acetone. This compound is moderately reactive, particularly towards nucleophilic substitution reactions. It exhibits weak acidity and can undergo various transformations in organic synthesis.

7-Fluoro-2,3-dihydro-4H-chromen-4-one can be synthesized via a Wittig reaction, where a phosphonate ester is reacted with an aldehyde in the presence of a base like triphenylphosphine. This method provides good selectivity and yields, making it a common approach in the organic synthesis literature.

7-Fluoro-2,3-dihydro-4H-chromen-4-one has applications in pharmaceuticals, where it serves as a precursor in the development of novel drug candidates. It also finds uses in the polymer industry for the synthesis of advanced materials, and in the sensor and semiconductor sectors due to its unique optical and electronic properties.

When handling 7-fluoro-2,3-dihydro-4H-chromen-4-one, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated environment or fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be ventilated. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.